Overview of Oral Potentially Malignant Disorders: From Risk Factors to Specific Therapies.

ABSTRACT: Oral squamous cell carcinoma (OSCC) is a very aggressive cancer, representing one of the most common malignancies worldwide. Oral potentially malignant disorders (OPMDs) regroup a variegate set of different histological lesions, characterized by the potential capacity to transform in OSCC. Most of the risk factors associated with OSCC are present also in OPMDs' development; however, the molecular mechanisms and steps of malignant transformation are still unknown. Treatment of OSCC, including surgery, systemic therapy and radiotherapy (alone or in combination), has suffered a dramatic change in last years, especially with the introduction of immunotherapy. However, most cases are diagnosed during the advanced stage of the disease, decreasing drastically the survival rate of the patients. He

SUBMITTER: Lorini L 

PROVIDER: S-EPMC8345150 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature