Identification of an RNA-Binding-Protein-Based Prognostic Model for Ewing Sarcoma.

ABSTRACT: RNA-binding proteins (RBPs) are important transcriptomic regulators and may be important in tumorigenesis. Here, we sought to investigate the clinical impact of RBPs for patients with Ewing sarcoma (ES). ES transcriptome signatures were characterized from four previously published cohorts and grouped into new training and validation cohorts. A total of three distinct subtypes were identified and compared for differences in patient prognosis and RBP signatures. Next, univariate Cox and Lasso regression models were used to identify hub prognosis-related RBPs and construct a prognostic risk model, and prediction capacity was assessed through time-dependent receiver operating characteristics (ROCs), Kaplan-Meier curves, and nomograms. Across the three RBP subtypes, 29 significant prognostic-as

SUBMITTER: Chen Y 

PROVIDER: S-EPMC8345188 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature