Associations between total MRI-visible small vessel disease burden and domain-specific cognitive abilities in a community-dwelling older-age cohort.

ABSTRACT: Cerebral small vessel disease (SVD) is a leading cause of vascular cognitive impairment, however the precise nature of SVD-related cognitive deficits, and their associations with structural brain changes, remain unclear. We combined computational volumes and visually-rated MRI markers of SVD to quantify total SVD burden, using data from the Lothian Birth Cohort 1936 (n = 540; age: 72.6 ± 0.7 years). We found negative associations between total SVD burden and general cognitive ability (standardized β: -0.363; 95%CI: [-0.49, -0.23]; p_(FDR) < 0.001), processing speed (-0.371 [-0.50, -0.24]; p_(FDR) < 0.001), verbal memory (-0.265; [-0.42, -0.11]; p_(FDR) = 0.002), and visuospatial ability (-0.170; [-0.32, -0.02]; p_(FDR) = 0.029). Only the association

SUBMITTER: Hamilton O 

PROVIDER: S-EPMC8345313 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature