The Role of Natural Killer Cells in Soft Tissue Sarcoma: Prospects for Immunotherapy.

ABSTRACT: Soft-tissue sarcomas (STS) represent about 80% of sarcomas, and are a heterogeneous group of rare and malignant tumors. STS arise from mesenchymal tissues and can grow into structures such as adipose tissue, muscles, nervous tissue and blood vessels. Morphological evaluation has been the standard model for the diagnosis of sarcomas, and even in samples with similar characteristics, they present a diversity in cytogenetic and genetic sequence alterations, which further increases the diversity of sarcomas. This variety is one of the main challenges for the classification and understanding of STS patterns, as well as for their respective treatments, which further decreases patient survival (<5 years). Despite some studies, little is known about the immunological profile of STS. As for the imm

SUBMITTER: Fortes-Andrade T 

PROVIDER: S-EPMC8345358 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature