Evaluation of Colon-Specific Plasma Nanovesicles as New Markers of Colorectal Cancer.

ABSTRACT:

Purpose

Developing new and efficient approaches for the early diagnosis of colorectal cancer (CRC) is an important issue. Circulating extracellular nanovesicles (ENVs) present a promising class of cancer markers. Cells of well-differentiated adenocarcinomas retain the molecular characteristics of colon epithelial cells, and the ENVs secreted by these cells may have colon-specific surface markers. We hypothesize that an increase in the number of ENVs carrying colon-specific markers could serve as a diagnostic criterion for colorectal cancer.

Experimental design

Potential colon-specific markers were selected based on tissue-specific expression profile and cell surface membrane localization data. Plasma was collected from CRC patients (n = 48) and healthy donors (n = 50). The t

SUBMITTER: Nazarova I 

PROVIDER: S-EPMC8345452 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature