Gender-Dependent Specificities in Cutaneous Melanoma Predisposition, Risk Factors, Somatic Mutations, Prognostic and Predictive Factors: A Systematic Review.

ABSTRACT:

Background and aim

Over the last decades, the incidence of melanoma has been steadily growing, with 4.2% of the population worldwide affected by cutaneous melanoma (CM) in 2020 and with a higher incidence and mortality in men than in women. We investigated both the risk factors for CM development and the prognostic and predictive factors for survival, stratifying for both sex and gender.

Methods

We conducted a systematic review of studies indexed in PUB-MED, EMBASE, and Scopus until 4 February 2021. We included reviews, meta-analyses, and pooled analyses investigating differences between women and men in CM risk factors and in prognostic and predictive factors for CM survival.

Data synthesis

Twenty-four studies were included, and relevant data extracted. Of these, 13

SUBMITTER: D'Ecclesiis O 

PROVIDER: S-EPMC8345480 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature