Recent Advances in the Delivery Carriers and Chemical Conjugation Strategies for Nucleic Acid Drugs.

ABSTRACT: With the development of new anticancer medicines, novel modalities are being explored for cancer treatment. For many years, conventional modalities, such as small chemical drugs and antibody drugs, have worked by "inhibiting the function" of target proteins. In recent years, however, nucleic acid drugs, such as ASOs and siRNAs, have attracted attention as a new modality for cancer treatment because nucleic acid drugs can directly promote the "loss of function" of target genes. Recently, nucleic acid drugs for use in cancer therapy have been extensively developed and some of them have currently been under investigation in clinical trials. To develop novel nucleic acid drugs for cancer treatment, it is imperative that cancer researchers, including ourselves, cover and understand those latest

SUBMITTER: Oyama S 

PROVIDER: S-EPMC8345803 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature