A Potential Oncogenic Role for PFKFB3 Overexpression in Gastric Cancer Progression.

ABSTRACT:

Objectives

PFKFB3 regulates glycolysis in tumor cells, might function as an oncogene, and is associated with cancer metastasis. However, its role in gastric cancer (GC) remains largely unknown.

Methods

PFKFB3 expression was assessed by immunohistochemistry (IHC) in GC tissues and paired paracancerous histological normal tissues (PCHNTs). The associations of PFKFB3 expression with clinical features and HIF-1α, Ki-67, E-cadherin, Snail, and Vimentin expression levels were assessed. A series of in vivo and in vitro experiments were performed to investigate the effects of PFKFB3 on the growth, migration, and invasion of GC cells.

Results

We found that PFKFB3 expression was significantly higher in GC tissues compared with PCHNTs (P = 0.000). PFKFB3 expression was positivel

SUBMITTER: Lei L 

PROVIDER: S-EPMC8345915 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature