Potential Therapeutic Approaches through Modulating the Autophagy Process for Skin Barrier Dysfunction.

ABSTRACT: Autophagy is an attractive process to researchers who are seeking novel potential treatments for various diseases. Autophagy plays a critical role in degrading damaged cellular organelles, supporting normal cell development, and maintaining cellular homeostasis. Because of the various effects of autophagy, recent human genome research has focused on evaluating the relationship between autophagy and a wide variety of diseases, such as autoimmune diseases, cancers, and inflammatory diseases. The skin is the largest organ in the body and provides the first line of defense against environmental hazards, including UV damage, chemical toxins, injuries, oxidative stress, and microorganisms. Autophagy takes part in endogenous defense mechanisms by controlling skin homeostasis. In this manner, regu

SUBMITTER: Choi MS 

PROVIDER: S-EPMC8345957 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature