Differential Expression of Peroxisomal Proteins in Distinct Types of Parotid Gland Tumors.

ABSTRACT: Salivary gland cancers are rare but aggressive tumors that have poor prognosis and lack effective cure. Of those, parotid tumors constitute the majority. Functioning as metabolic machinery contributing to cellular redox balance, peroxisomes have emerged as crucial players in tumorigenesis. Studies on murine and human cells have examined the role of peroxisomes in carcinogenesis with conflicting results. These studies either examined the consequences of altered peroxisomal proliferators or compared their expression in healthy and neoplastic tissues. None, however, examined such differences exclusively in human parotid tissue or extended comparison to peroxisomal proteins and their associated gene expressions. Therefore, we examined differences in peroxisomal dynamics in parotid tumors of di

SUBMITTER: Meyer MT 

PROVIDER: S-EPMC8345988 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature