Males and Females Have Distinct Molecular Events in the Articular Cartilage during Knee Osteoarthritis.

ABSTRACT: Osteoarthritis (OA) is a major public health challenge that imposes a remarkable burden on the affected individuals and the healthcare system. Based on the clinical observation, males and females have different prevalence rates and severity levels of OA. Thus, sex-based differences may play essential roles in OA's prognosis and treatment outcomes. To date, the comprehensive understanding of the relationship between sex and OA is still largely lacking. In the current study, we analyzed a published transcriptome dataset of knee articular cartilage (GSE114007) from 18 healthy (five females, 13 males) and 20 OA (11 females, nine males) donors to provide a slight insight into this important but complex issue. First, comparing female healthy cartilage samples with those of males revealed 36 diff

SUBMITTER: Li C 

PROVIDER: S-EPMC8346087 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature