Diverse Functions of Tim50, a Component of the Mitochondrial Inner Membrane Protein Translocase.

ABSTRACT: Mitochondria are essential in eukaryotes. Besides producing 80% of total cellular ATP, mitochondria are involved in various cellular functions such as apoptosis, inflammation, innate immunity, stress tolerance, and Ca²⁺ homeostasis. Mitochondria are also the site for many critical metabolic pathways and are integrated into the signaling network to maintain cellular homeostasis under stress. Mitochondria require hundreds of proteins to perform all these functions. Since the mitochondrial genome only encodes a handful of proteins, most mitochondrial proteins are imported from the cytosol via receptor/translocase complexes on the mitochondrial outer and inner membranes known as TOMs and TIMs. Many of the subunits of these protein complexes are essential for cell survival in model y

SUBMITTER: Chaudhuri M 

PROVIDER: S-EPMC8346121 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature