NF1 mutation drives neuronal activity-dependent initiation of optic glioma.

ABSTRACT: Neurons have recently emerged as essential cellular constituents of the tumour microenvironment, and their activity has been shown to increase the growth of a diverse number of solid tumours¹. Although the role of neurons in tumour progression has previously been demonstrated², the importance of neuronal activity to tumour initiation is less clear-particularly in the setting of cancer predisposition syndromes. Fifteen per cent of individuals with the neurofibromatosis 1 (NF1) cancer predisposition syndrome (in which tumours arise in close association with nerves) develop low-grade neoplasms of the optic pathway (known as optic pathway gliomas (OPGs)) during early childhood^3,4, raising  the possibility that postnatal light-induced activity of the optic nerve

SUBMITTER: Pan Y 

PROVIDER: S-EPMC8346229 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature