SARS-CoV-2 spike protein and RNA dependent RNA polymerase as targets for drug and vaccine development: A review.

ABSTRACT: The present pandemic has posed a crisis to the economy of the world and the health sector. Therefore, the race to expand research to understand some good molecular targets for vaccine and therapeutic development for SARS-CoV-2 is inevitable. The newly discovered coronavirus 2019 (COVID-19) is a positive sense, single-stranded RNA, and enveloped virus, assigned to the beta CoV genus. The virus (SARS-CoV-2) is more infectious than the previously detected coronaviruses (MERS and SARS). Findings from many studies have revealed that S protein and RdRp are good targets for drug repositioning, novel therapeutic development (antibodies and small molecule drugs), and vaccine discovery. Therapeutics such as chloroquine, convalescent plasma, monoclonal antibodies, spike binding peptides, and small mo

SUBMITTER: Muhammed Y 

PROVIDER: S-EPMC8346354 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature