Dataset Information

Impact of alcohol abstinence on survival after hepatic resection for hepatocellular carcinoma in patients with alcohol-related liver disease.

ABSTRACT:

Background

This study aimed to evaluate the prognostic impact of alcohol abstinence on survival after hepatic resection for hepatocellular carcinoma (HCC) in patients with alcohol-related liver disease (ALD).

Patients and methods

In total, 92 patients with ALD-HCC who underwent initial and curative hepatic resection were identified, including 56 and 36 patients with and without alcohol abstinence, respectively.

Results

The 3-, 5-, and 7-year recurrence-free survival (RFS) were 46%, 43%, and 37% in the abstinence group, and 61%, 36%, and 36% in the non-abstinence group, respectively (p = 0.71). The 3-, 5-, and 7-year overall survival (OS) were 91%, 76%, and 66% in the abstinence group, and 87%, 57%, and 44% in the non-abstinence group, respectively (p = 0.023). Multivariate analysis revealed that non-abstinence was an independent prognostic factor for OS (P = 0.026). The incidence rate of liver-related death including HCC-specific death, liver failure, and renal failure in cirrhosis (hepatorenal syndrome) between the non-abstinence and abstinence groups were 41.7% vs. 19.6% (p = 0.032). Worsening of the Child-Pugh grade at intrahepatic recurrence was more frequently observed in the non-abstinence (33.3%) than that in the abstinence group (6.5%) (p = 0.039).

Conclusions

Alcohol abstinence might improve the long-term survival of patients with ALD-HCC undergoing hepatic resection.

SUBMITTER: Shirai D

PROVIDER: S-EPMC8346358 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature

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Publications

Impact of alcohol abstinence on survival after hepatic resection for hepatocellular carcinoma in patients with alcohol-related liver disease.

Shirai Daisuke D Shinkawa Hiroji H Takemura Shigekazu S Tanaka Shogo S Amano Ryosuke R Kimura Kenjiro K Kinoshita Masahiko M Kawada Norifumi N Kubo Shoji S

Annals of medicine and surgery (2012) 20210729

<h4>Background</h4>This study aimed to evaluate the prognostic impact of alcohol abstinence on survival after hepatic resection for hepatocellular carcinoma (HCC) in patients with alcohol-related liver disease (ALD).<h4>Patients and methods</h4>In total, 92 patients with ALD-HCC who underwent initial and curative hepatic resection were identified, including 56 and 36 patients with and without alcohol abstinence, respectively.<h4>Results</h4>The 3-, 5-, and 7-year recurrence-free survival (RFS) w ...[more]

PMID: 34386231

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Dataset Information

Impact of alcohol abstinence on survival after hepatic resection for hepatocellular carcinoma in patients with alcohol-related liver disease.

Background

Patients and methods

Results

Conclusions

Publications

Impact of alcohol abstinence on survival after hepatic resection for hepatocellular carcinoma in patients with alcohol-related liver disease.

Similar Datasets

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