Excess sucrose intake during pregnancy programs fetal brain glucocorticoid receptor expression in female but not male C57Bl/6J mice.

ABSTRACT:

Background

Sex-specific mechanisms explaining the association between mothers with obesity and the development of obesity in children are poorly characterized. Permanent changes in fetal brain glucocorticoid receptor (GR) expression caused by exposure to overnutrition in utero may program aberrant energy homeostasis, thereby predisposing the offspring to obesity. This study explores sex differences in brain GR expression using an established mouse model of overnutrition during pregnancy.

Methods

Female C57Bl/6J mice were fed control (CON) or high-fat-high-sucrose (HFHS) diets. Dam cholesterol, insulin, and triglycerides were measured by colorimetric assays. Fetal corticosterone exposure was measured by placental Abca1, Hsd11β1, Hsd11β2, and brain

SUBMITTER: Kulhanek D 

PROVIDER: S-EPMC8346374 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature