Ontology highlight
ABSTRACT:
SUBMITTER: Berger DJ
PROVIDER: S-EPMC8346512 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Berger Duncan J DJ Crellen Thomas T Lamberton Poppy H L PHL Allan Fiona F Tracey Alan A Noonan Jennifer D JD Kabatereine Narcis B NB Tukahebwa Edridah M EM Adriko Moses M Holroyd Nancy N Webster Joanne P JP Berriman Matthew M Cotton James A JA
Nature communications 20210806 1
Control and elimination of the parasitic disease schistosomiasis relies on mass administration of praziquantel. Whilst these programmes reduce infection prevalence and intensity, their impact on parasite transmission and evolution is poorly understood. Here we examine the genomic impact of repeated mass drug administration on Schistosoma mansoni populations with documented reduced praziquantel efficacy. We sequenced whole-genomes of 198 S. mansoni larvae from 34 Ugandan children from regions wit ...[more]