Ontology highlight
ABSTRACT:
SUBMITTER: Zhang J
PROVIDER: S-EPMC8346516 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Zhang Jiyuan J Guan Xin X Shah Kunal K Yan Jiusheng J
Nature communications 20210806 1
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent Ca<sup>2+</sup>-mobilizing second messenger which uniquely mobilizes Ca<sup>2+</sup> from acidic endolysosomal organelles. However, the molecular identity of the NAADP receptor remains unknown. Given the necessity of the endolysosomal two-pore channel (TPC1 or TPC2) in NAADP signaling, we performed affinity purification and quantitative proteomic analysis of the interacting proteins of NAADP and TPCs. We identified a Sm-like prote ...[more]