Collagen fiber orientation disorder from H&E images is prognostic for early stage breast cancer: clinical trial validation.

ABSTRACT: Collagen fiber organization has been found to be implicated in breast cancer prognosis. In this study, we evaluated whether computerized features of Collagen Fiber Orientation Disorder in Tumor-associated Stroma (CFOD-TS) on Hematoxylin & Eosin (H&E) slide images were prognostic of Disease Free Survival (DFS) in early stage Estrogen Receptor Positive (ER+) Invasive Breast Cancers (IBC). A Cox regression model named M_CFOD-TS, was constructed using cohort S_t (N = 78) to predict DFS based on CFOD-TS features. The prognostic performance of M_CFOD-TS was validated on cohort S_v (N = 219), a prospective clinical trial dataset (ECOG 2197). M_CFOD-TS was prognostic of DFS in both S_t and S_v, independent of clinicopathological

SUBMITTER: Li H 

PROVIDER: S-EPMC8346522 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature