Magnesium ions regulate mesenchymal stem cells population and osteogenic differentiation: A fuzzy agent-based modeling approach.

ABSTRACT: Mesenchymal stem cells (MSCs) are proliferative and multipotent cells that play a key role in the bone regeneration process. Empirical data have repeatedly shown the bioregulatory importance of magnesium (Mg) ions in MSC growth and osteogenesis. In this study, we propose an agent-based model to predict the spatiotemporal dynamics of the MSC population and osteogenic differentiation in response to Mg²⁺ ions. A fuzzy-logic controller was designed to govern the decision-making process of cells by predicting four cellular processes of proliferation, differentiation, migration, and mortality in response to several important bioregulatory factors such as Mg²⁺ ions, pH, BMP2, and TGF-β1. The model was calibrated using the empirical data obtained from three sets of cell cultu

SUBMITTER: Nourisa J 

PROVIDER: S-EPMC8346546 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature