Gene expression profiles compared in environmental and malnutrition enteropathy in Zambian children and adults.

ABSTRACT:

Background

Environmental enteropathy (EE) contributes to growth failure in millions of children worldwide, but its relationship to clinical malnutrition has not been elucidated. We used RNA sequencing to compare duodenal biopsies from adults and children with EE, and from children with severe acute malnutrition (SAM), to define key features of these malnutrition-related enteropathies.

Methods

RNA was extracted and sequenced from biopsies of children with SAM in hospital (n=27), children with non-responsive stunting in the community (n=30), and adults living in the same community (n=37) using an identical sequencing and analysis pipeline. Two biopsies each were profiled and differentially expressed genes (DEGs) were computed from the comparisons of the three groups. DEG lists

SUBMITTER: Kelly P 

PROVIDER: S-EPMC8346547 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature