Male Infertility Knowledgebase: decoding the genetic and disease landscape.

ABSTRACT: Male infertility is a multifactorial condition that contributes to around one-third of cases of infertility worldwide. Several chromosomal aberrations, single-gene and polygenic associations with male factor defects have been reported. These defects manifest as sperm number or sperm quality defects leading to infertility. However, in almost 40% of cases, the genetic etiology of male infertility remains unexplained. Understanding the causal genetic factors is crucial for effective patient management and counseling. Integrating the vast amount of available omics data on male infertility is a first step towards understanding, delineating and prioritizing genes associated with the different male reproductive disorders. The Male Infertility Knowledgebase (MIK) is a manually curated repository d

SUBMITTER: Joseph S 

PROVIDER: S-EPMC8346693 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature