Using Risk Stratification to Optimize Mammography Screening in Chinese Women.

ABSTRACT:

Background

The cost-effectiveness of mammography screening among Chinese women remains contentious. Here, we characterized breast cancer (BC) epidemiology in Hong Kong and evaluated the cost-effectiveness of personalized risk-based screening.

Methods

We used the Hong Kong Breast Cancer Study (a case-control study with 3501 cases and 3610 controls) and Hong Kong Cancer Registry to develop a risk stratification model based on well-documented risk factors. We used the Shanghai Breast Cancer Study to validate the model. We considered risk-based programs with different screening age ranges and risk thresholds under which women were eligible to join if their remaining BC risk at the starting age exceeded the threshold.

Results

The lifetime risk (15-99 years) of BC ranged fr

SUBMITTER: Leung K 

PROVIDER: S-EPMC8346705 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature