On the emergence, spread and resistance of Candida auris: host, pathogen and environmental tipping points.

ABSTRACT: Over a decade ago, a multidrug-resistant nosocomial fungus Candida auris emerged worldwide and has since become a significant challenge for clinicians and microbiologists across the globe. A resilient pathogen, C. auris survives harsh disinfectants, desiccation and high-saline environments. It readily colonizes the inanimate environment, susceptible patients and causes invasive infections that exact a high toll. Prone to misidentification by conventional microbiology techniques, C. auris rapidly acquires multiple genetic determinants that confer multidrug resistance. Whole-genome sequencing has identified four distinct clades of C. auris, and possibly a fifth one, in circulation. Even as our understanding of this formidable pathogen grows, the nearly simultaneous emergence of its distinct

SUBMITTER: Chakrabarti A 

PROVIDER: S-EPMC8346726 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature