Emergence of carbapenem-resistant <i>Klebsiella pneumoniae</i> harbouring <i>bla</i> _OXA-48-like genes in China.

ABSTRACT: Klebsiella pneumoniae strains carrying OXA-48-like carbapenemases are increasingly prevalent across the globe. There is thus an urgent need to better understand the mechanisms that underpin the dissemination of bla _OXA-48-like carbapenemases. To this end, four ertapenem-resistant K. pneumoniae isolates producing OXA-48-like carbapenemases were isolated from two patients. Genome sequencing revealed that one sequence type (ST) 17 isolate carried bla _OXA-181, whilst three isolates from a single patient, two ST76 and one ST15, carried bla _OXA-232. The 50514 bp bla _OXA-181-harbouring plasmid, pOXA-181_YML0508, was X3-type with a conjugation frequency to Escherichia coli of 1.94×10^-4 transconj

SUBMITTER: Chen Y 

PROVIDER: S-EPMC8346730 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature