Fli1⁺ cells transcriptional analysis reveals an Lmo2-Prdm16 axis in angiogenesis.

ABSTRACT: A network of molecular factors drives the development, differentiation, and maintenance of endothelial cells. Friend leukemia integration 1 transcription factor (FLI1) is a bona fide marker of endothelial cells during early development. In zebrafish Tg(fli1:EGFP)^y1 , we identified two endothelial cell populations, high-fli1⁺ and low-fli1⁺, by the intensity of green fluorescent protein signal. By comparing RNA-sequencing analysis of non-fli1 expressing cells (fli1^-) with these two (fli1⁺) cell populations, we identified several up-regulated genes, not previously recognized as important, during endothelial development. Compared with fli1^- and low-fli1

SUBMITTER: Matrone G 

PROVIDER: S-EPMC8346798 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature