Investigating lymphangiogenesis in vitro and in vivo using engineered human lymphatic vessel networks.

ABSTRACT: The lymphatic system is involved in various biological processes, including fluid transport from the interstitium into the venous circulation, lipid absorption, and immune cell trafficking. Despite its critical role in homeostasis, lymphangiogenesis (lymphatic vessel formation) is less widely studied than its counterpart, angiogenesis (blood vessel formation). Although the incorporation of lymphatic vasculature in engineered tissues or organoids would enable more precise mimicry of native tissue, few studies have focused on creating engineered tissues containing lymphatic vessels. Here, we populated thick collagen sheets with human lymphatic endothelial cells, combined with supporting cells and blood endothelial cells, and examined lymphangiogenesis within the resulting constructs. Our mod

SUBMITTER: Landau S 

PROVIDER: S-EPMC8346860 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature