The p53 transcriptional response across tumor types reveals core and senescence-specific signatures modulated by long noncoding RNAs.

ABSTRACT: The p53 pathway is a universal tumor suppressor mechanism that limits tumor progression by triggering apoptosis or permanent cell cycle arrest, called senescence. In recent years, efforts to reactivate p53 function in cancer have proven to be a successful therapeutic strategy in murine models and have gained traction with the development of a range of small molecules targeting mutant p53. However, knowledge of the downstream mediators of p53 reactivation in different oncogenic contexts has been limited. Here, we utilized a panel of murine cancer cell lines from three distinct tumor types susceptible to alternative outcomes following p53 restoration to define unique and shared p53 transcriptional signatures. While we found that the majority of p53-bound sites and p53-responsive transcripts

SUBMITTER: Tesfaye E 

PROVIDER: S-EPMC8346867 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature