A comparative metabologenomic approach reveals mechanistic insights into Streptomyces antibiotic crypticity.

ABSTRACT: Streptomyces genomes harbor numerous, biosynthetic gene clusters (BGCs) encoding for drug-like compounds. While some of these BGCs readily yield expected products, many do not. Biosynthetic crypticity represents a significant hurdle to drug discovery, and the biological mechanisms that underpin it remain poorly understood. Polycyclic tetramate macrolactam (PTM) antibiotic production is widespread within the Streptomyces genus, and examples of active and cryptic PTM BGCs are known. To reveal further insights into the causes of biosynthetic crypticity, we employed a PTM-targeted comparative metabologenomics approach to analyze a panel of S. griseus clade strains that included both poor and robust PTM producers. By comparing the genomes and PTM production profiles of thes

SUBMITTER: Qi Y 

PROVIDER: S-EPMC8346890 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature