Mechanism of Ganglioside Receptor Recognition by Botulinum Neurotoxin Serotype E.

ABSTRACT: The botulinum neurotoxins are potent molecules that are not only responsible for the lethal paralytic disease botulism, but have also been harnessed for therapeutic uses in the treatment of an increasing number of chronic neurological and neuromuscular disorders, in addition to cosmetic applications. The toxins act at the cholinergic nerve terminals thanks to an efficient and specific mechanism of cell recognition which is based on a dual receptor system that involves gangliosides and protein receptors. Binding to surface-anchored gangliosides is the first essential step in this process. Here, we determined the X-ray crystal structure of the binding domain of BoNT/E, a toxin of clinical interest, in complex with its GD1a oligosaccharide receptor. Beyond confirmation of the conserved gangli

SUBMITTER: Masuyer G 

PROVIDER: S-EPMC8346984 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature