K-mer Content Changes with Node Degree in Promoter-Enhancer Network of Mouse ES Cells.

ABSTRACT: Maps of Hi-C contacts between promoters and enhancers can be analyzed as networks, with cis-regulatory regions as nodes and their interactions as edges. We checked if in the published promoter-enhancer network of mouse embryonic stem (ES) cells the differences in the node type (promoter or enhancer) and the node degree (number of regions interacting with a given promoter or enhancer) are reflected by sequence composition or sequence similarity of the interacting nodes. We used counts of all k-mers (k = 4) to analyze the sequence composition and the Euclidean distance between the k-mer count vectors (k-mer distance) as the measure of sequence (dis)similarity. The results we obtained with 4-mers are interpretable in terms of dinucleotides. Promoters are GC-rich as compared to enhancers, whic

SUBMITTER: Szyman K 

PROVIDER: S-EPMC8347099 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature