A Proteomic Study Suggests Stress Granules as New Potential Actors in Radiation-Induced Bystander Effects.

ABSTRACT: Besides the direct effects of radiations, indirect effects are observed within the surrounding non-irradiated area; irradiated cells relay stress signals in this close proximity, inducing the so-called radiation-induced bystander effect. These signals received by neighboring unirradiated cells induce specific responses similar with those of direct irradiated cells. To understand the cellular response of bystander cells, we performed a 2D gel-based proteomic study of the chondrocytes receiving the conditioned medium of low-dose irradiated chondrosarcoma cells. The conditioned medium was directly analyzed by mass spectrometry in order to identify candidate bystander factors involved in the signal transmission. The proteomic analysis of the bystander chondrocytes highlighted 20 proteins spots

SUBMITTER: Tudor M 

PROVIDER: S-EPMC8347418 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature