Atrazine Inhalation Causes Neuroinflammation, Apoptosis and Accelerating Brain Aging.

ABSTRACT:

Background

exposure to environmental contaminants has been linked to an increased risk of neurological diseases and poor outcomes. Chemical name of Atrazine (ATR) is 6-chloro-N-ethyl-N'-(1-methylethyl)-1,3,5-triazine-2,4-diamine, and it is the most commonly used broad-spectrum herbicide in agricultural crops. Several studies have demonstrated that ATR has the potential to be harmful to the brain's neuronal circuits. Until today nobody has explored the effect of ATR inhalation on young and aged mice.

Methods

young and aged mice were subject to 25 mg of ATR in a vehicle made with saline and 10% of Dimethyl sulfoxide (DMSO) every day for 28 days. At the end of experiment different behavioral test were made and brain was collected.

Results

exposure to ATR in

SUBMITTER: Genovese T 

PROVIDER: S-EPMC8347547 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature