Cells to the Rescue: Emerging Cell-Based Treatment Approaches for NMOSD and MOGAD.

ABSTRACT: Cell-based therapies are gaining momentum as promising treatments for rare neurological autoimmune diseases, including neuromyelitis optica spectrum disorders and myelin oligodendrocyte glycoprotein antibody-associated disease. The development of targeted cell therapies is hampered by the lack of adequate animal models that mirror the human disease. Most cell-based treatments, including HSCT, CAR-T cell, tolerogenic dendritic cell and mesenchymal stem cell treatment have entered early stage clinical trials or have been used as rescue treatment in treatment-refractory cases. The development of antigen-specific cell-based immunotherapies for autoimmune diseases is slowed down by the rarity of the diseases, the lack of surrogate outcomes and biomarkers that are able to predict long-term outco

SUBMITTER: Derdelinckx J 

PROVIDER: S-EPMC8347572 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature