Development of [18F]LU14 for PET Imaging of Cannabinoid Receptor Type 2 in the Brain.
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ABSTRACT:
SUBMITTER: Teodoro R
PROVIDER: S-EPMC8347709 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
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Development of [<sup>18</sup>F]LU14 for PET Imaging of Cannabinoid Receptor Type 2 in the Brain.
Teodoro Rodrigo R Gündel Daniel D Deuther-Conrad Winnie W Ueberham Lea L Toussaint Magali M Bormans Guy G Brust Peter P Moldovan Rareş-Petru RP
International journal of molecular sciences 20210728 15
Cannabinoid receptors type 2 (CB2R) represent an attractive therapeutic target for neurodegenerative diseases and cancer. Aiming at the development of a positron emission tomography (PET) radiotracer to monitor receptor density and/or occupancy during a CB2R-tailored therapy, we herein describe the radiosynthesis of <i>cis</i>-[<sup>18</sup>F]1-(4-fluorobutyl-<i>N</i>-((1s,4s)-4-methylcyclohexyl)-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxamide ([<sup>18</sup>F]<b>LU14</b>) starting from the co ...[more]
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