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Δ8(14)-Ergostenol Glycoside Derivatives Inhibit the Expression of Inflammatory Mediators and Matrix Metalloproteinase.

ABSTRACT: Arthritis is a chronic inflammatory disease accompanied by pathological reactions such as swelling, redness, fever, and pain in various joint areas. The drugs currently available to treat arthritis are associated with diverse side-effects. Therefore, there is a need for safer and more effective treatments to alleviate the inflammation of arthritis with fewer side-effects. In this study, a new sterol, Δ8(14)-ergostenol, was discovered, and its glycosides were synthesized and found to be more efficient in terms of synthesis or anti-inflammatory activity than either spinasterol or 5,6-dihydroergosterol is. Among these synthetic glycosides, galactosyl ergostenol inhibited the expression of inflammatory mediators in TNF-α-stimulated FLS and TNF-α-induced MMPs and collagen type II A1 degradation in human chondrocytes. These results suggest the new galactosyl ergostenol as a treatment candidate for arthritis.

SUBMITTER: Moon H 

PROVIDER: S-EPMC8347845 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature

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Δ<sup>8(14)</sup>-Ergostenol Glycoside Derivatives Inhibit the Expression of Inflammatory Mediators and Matrix Metalloproteinase.

Moon Hyejin H   Ko Myoungsil M   Park Yujin Y   Kim Jeonguk J   Yoon Dowon D   Lee Eunjoohwang E   Lee Taehoon T   Kim Hakwon H  

Molecules (Basel, Switzerland) 20210728 15

Arthritis is a chronic inflammatory disease accompanied by pathological reactions such as swelling, redness, fever, and pain in various joint areas. The drugs currently available to treat arthritis are associated with diverse side-effects. Therefore, there is a need for safer and more effective treatments to alleviate the inflammation of arthritis with fewer side-effects. In this study, a new sterol, Δ<sup>8(14)</sup>-ergostenol, was discovered, and its glycosides were synthesized and found to b  ...[more]

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