Performance Analysis of Non-Interferometry Based Surface Plasmon Resonance Microscopes.

ABSTRACT: Surface plasmon microscopy has been of interest to the science and engineering community and has been utilized in broad aspects of applications and studies, including biochemical sensing and biomolecular binding kinetics. The benefits of surface plasmon microscopy include label-free detection, high sensitivity, and quantitative measurements. Here, a theoretical framework to analyze and compare several non-interferometric surface plasmon microscopes is proposed. The scope of the study is to (1) identify the strengths and weaknesses in each surface plasmon microscopes reported in the literature; (2) quantify their performance in terms of spatial imaging resolution, imaging contrast, sensitivity, and measurement accuracy for quantitative and non-quantitative imaging modes of the microscopes.

SUBMITTER: Tontarawongsa S 

PROVIDER: S-EPMC8347916 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature