Cardiolipin-Containing Lipid Membranes Attract the Bacterial Cell Division Protein DivIVA.

ABSTRACT: DivIVA is a protein initially identified as a spatial regulator of cell division in the model organism Bacillus subtilis, but its homologues are present in many other Gram-positive bacteria, including Clostridia species. Besides its role as topological regulator of the Min system during bacterial cell division, DivIVA is involved in chromosome segregation during sporulation, genetic competence, and cell wall synthesis. DivIVA localizes to regions of high membrane curvature, such as the cell poles and cell division site, where it recruits distinct binding partners. Previously, it was suggested that negative curvature sensing is the main mechanism by which DivIVA binds to these specific regions. Here, we show that Clostridioides difficile DivIVA binds preferably to membr

SUBMITTER: Labajova N 

PROVIDER: S-EPMC8348161 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature