Ontology highlight
ABSTRACT:
SUBMITTER: Wei X
PROVIDER: S-EPMC8348608 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Wei Xiaofan X Maharjan Yunash Y Dorotea Debra D Dutta Raghbendra-Kumar RK Kim Donghyun D Kim Hyunsoo H Mu Yizhu Y Park Channy C Park Raekil R
International journal of molecular sciences 20210726 15
Peroxisome abundance is regulated by homeostasis between the peroxisomal biogenesis and degradation processes. Peroxin 16 (PEX16) is a peroxisomal protein involved in trafficking membrane proteins for de novo peroxisome biogenesis. The present study demonstrates that PEX16 also modulates peroxisome abundance through pexophagic degradation. PEX16 knockdown in human retinal pigment epithelial-1 cells decreased peroxisome abundance and function, represented by reductions in the expression of peroxi ...[more]