Metabolic impairment of non-small cell lung cancers by mitochondrial HSPD1 targeting.

ABSTRACT:

Background

The identification of novel targets is of paramount importance to develop more effective drugs and improve the treatment of non-small cell lung cancer (NSCLC), the leading cause of cancer-related deaths worldwide. Since cells alter their metabolic rewiring during tumorigenesis and along cancer progression, targeting key metabolic players and metabolism-associated proteins represents a valuable approach with a high therapeutic potential. Metabolic fitness relies on the functionality of heat shock proteins (HSPs), molecular chaperones that facilitate the correct folding of metabolism enzymes and their assembly in macromolecular structures.

Methods

Gene fitness was determined by bioinformatics analysis from available datasets from genetic screenings. HSPD1 expression

SUBMITTER: Parma B 

PROVIDER: S-EPMC8348813 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature