Exploiting genomic synteny in Felidae: cross-species genome alignments and SNV discovery can aid conservation management.

ABSTRACT:

Background

While recent advances in genomics has enabled vast improvements in the quantification of genome-wide diversity and the identification of adaptive and deleterious alleles in model species, wildlife and non-model species have largely not reaped the same benefits. This has been attributed to the resources and infrastructure required to develop essential genomic datasets such as reference genomes. In the absence of a high-quality reference genome, cross-species alignments can provide reliable, cost-effective methods for single nucleotide variant (SNV) discovery. Here, we demonstrated the utility of cross-species genome alignment methods in gaining insights into population structure and functional genomic features in cheetah (Acinonyx jubatas), snow leopard (Panthera uncia) a

SUBMITTER: Samaha G 

PROVIDER: S-EPMC8348863 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature