Analysis of Spatial and Temporal Distribution of Purinergic P2 Receptors in the Mouse Hippocampus.

ABSTRACT: ATP and other nucleotides are important glio-/neurotransmitters in the central nervous system. They bind to purinergic P2X and P2Y receptors that are ubiquitously expressed in various brain regions modulating various physiological and pathophysiological processes. P2X receptors are ligand-gated ion channels mediating excitatory postsynaptic responses whereas P2Y receptors are G protein-coupled receptors mediating slow synaptic transmission. A variety of P2X and P2Y subtypes with distinct neuroanatomical localization provide the basis for a high diversity in their function. There is increasing evidence that P2 receptor signaling plays a prominent role in learning and memory and thus, in hippocampal neuronal plasticity. Learning and memory are time-of-day-dependent. Moreover, extracellular A

SUBMITTER: Lommen J 

PROVIDER: S-EPMC8348931 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature