Netrin-1 in Glioblastoma Neovascularization: The New Partner in Crime?

ABSTRACT: Glioblastoma (GBM) is the most aggressive and common primary tumor of the central nervous system. It is characterized by having an infiltrating growth and by the presence of an excessive and aberrant vasculature. Some of the mechanisms that promote this neovascularization are angiogenesis and the transdifferentiation of tumor cells into endothelial cells or pericytes. In all these processes, the release of extracellular microvesicles by tumor cells plays an important role. Tumor cell-derived extracellular microvesicles contain pro-angiogenic molecules such as VEGF, which promote the formation of blood vessels and the recruitment of pericytes that reinforce these structures. The present study summarizes and discusses recent data from different investigations suggesting that Netrin-1, a high

SUBMITTER: Vasquez X 

PROVIDER: S-EPMC8348949 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature