Ontology highlight
ABSTRACT:
SUBMITTER: Mamun AA
PROVIDER: S-EPMC8348983 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Mamun Abdullah Al AA Pidaný Filip F Hulcová Daniela D Maříková Jana J Kučera Tomáš T Schmidt Monika M Catapano Maria Carmen MC Hrabinová Martina M Jun Daniel D Múčková Lubica L Kuneš Jiří J Janoušek Jiří J Andrýs Rudolf R Nováková Lucie L Peřinová Rozálie R Maafi Negar N Soukup Ondřej O Korábečný Jan J Cahlíková Lucie L
International journal of molecular sciences 20210802 15
Alzheimer's disease (AD) is a multifactorial neurodegenerative condition of the central nervous system (CNS) that is currently treated by cholinesterase inhibitors and the <i>N</i>-methyl-d-aspartate receptor antagonist, memantine. Emerging evidence strongly supports the relevance of targeting butyrylcholinesterase (BuChE) in the more advanced stages of AD. Within this study, we have generated a pilot series of compounds (<b>1</b>-<b>20</b>) structurally inspired from belladine-type Amaryllidace ...[more]