Neuronal Dystroglycan regulates postnatal development of CCK/cannabinoid receptor-1 interneurons.

ABSTRACT:

Background

The development of functional neural circuits requires the precise formation of synaptic connections between diverse neuronal populations. The molecular pathways that allow GABAergic interneuron subtypes in the mammalian brain to initially recognize their postsynaptic partners remain largely unknown. The transmembrane glycoprotein Dystroglycan is localized to inhibitory synapses in pyramidal neurons, where it is required for the proper function of CCK+ interneurons. However, the precise temporal requirement for Dystroglycan during inhibitory synapse development has not been examined.

Methods

In this study, we use NEX^Cre or Camk2a^CreERT2 to conditionally delete Dystroglycan from newly-born or adult pyramidal neurons, respectively. We then anal

SUBMITTER: Miller DS 

PROVIDER: S-EPMC8349015 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature