Placental ¹³C-DHA metabolism and relationship with maternal BMI, glycemia and birthweight.

ABSTRACT:

Background

Fetal docosahexaenoic acid (DHA) supply relies on preferential transplacental transfer, which is regulated by placental DHA lipid metabolism. Maternal hyperglycemia and obesity associate with higher birthweight and fetal DHA insufficiency but the role of placental DHA metabolism is unclear.

Methods

Explants from 17 term placenta were incubated with ¹³C-labeled DHA for 48 h, at 5 or 10 mmol/L glucose treatment, and the production of 17 individual newly synthesized ¹³C-DHA labeled lipids quantified by liquid chromatography mass spectrometry.

Results

Maternal BMI positively associated with ¹³C-DHA-labeled diacylglycerols, triacylglycerols, lysophospholipids, phosphatidylcholine and phosphatidylethanolamine plasmalogens, while m

SUBMITTER: Watkins OC 

PROVIDER: S-EPMC8349043 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature