Pregnancy exposure of titanium dioxide nanoparticles causes intestinal dysbiosis and neurobehavioral impairments that are not significant postnatally but emerge in adulthood of offspring.

ABSTRACT:

Background

Pregnancy exposure to titanium dioxide nanoparticles (TiO₂NPs) is a vital consideration due to their inadvertent ingestion from environmental contamination. The potential health effects of TiO₂NPs on the neurodevelopmental process should be seriously concerned in health risk assessment, especially for the pregnant women who are susceptible to the neurodevelopmental toxicity of nano-sized particles. However, the available evidence of neurodevelopmental toxicity of TiO₂NPs remains very limited.

Methods

In the present study, the pregnant mice were intragastric administered with 150 mg/kg TiO₂NPs from gestational day (GD) 8 to 21, the maternal behaviors and neurodevelopment-related indicators in offspring were all assessed a

SUBMITTER: Su J 

PROVIDER: S-EPMC8349049 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature