Type 1 diabetes in pregnancy is associated with distinct changes in the composition and function of the gut microbiome.

ABSTRACT:

Background

The gut microbiome changes in response to a range of environmental conditions, life events and disease states. Pregnancy is a natural life event that involves major physiological adaptation yet studies of the microbiome in pregnancy are limited and their findings inconsistent. Pregnancy with type 1 diabetes (T1D) is associated with increased maternal and fetal risks but the gut microbiome in this context has not been characterized. By whole metagenome sequencing (WMS), we defined the taxonomic composition and function of the gut bacterial microbiome across 70 pregnancies, 36 in women with T1D.

Results

Women with and without T1D exhibited compositional and functional changes in the gut microbiome across pregnancy. Profiles in women with T1D were distinct, with an i

SUBMITTER: Roth-Schulze AJ 

PROVIDER: S-EPMC8349100 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature