Biomarker-Calibrated Macronutrient Intake and Chronic Disease Risk among Postmenopausal Women.

ABSTRACT:

Background

Knowledge about macronutrient intake and chronic disease risk has been limited by the absence of objective macronutrient measures. Recently, we proposed novel biomarkers for protein, protein density, carbohydrate, and carbohydrate density, using established biomarkers and serum and urine metabolomics profiles in a human feeding study.

Objectives

We aimed to use these biomarkers to develop calibration equations for macronutrient variables using dietary self-reports and personal characteristics and to study the association between biomarker-calibrated intake estimates and cardiovascular disease, cancer, and diabetes risk in Women's Health Initiative (WHI) cohorts.

Methods

Prospective disease association analyses are based on WHI cohorts of postmenopausal US w

SUBMITTER: Prentice RL 

PROVIDER: S-EPMC8349120 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature