Diets Varying in Carbohydrate Content Differentially Alter Brain Activity in Homeostatic and Reward Regions in Adults.

ABSTRACT:

Background

Obesity has one of the highest refractory rates of all chronic diseases, in part because weight loss induced by calorie restriction, the first-line treatment for obesity, elicits biological adaptations that promote weight regain. Although acute feeding trials suggest a role for macronutrient composition in modifying brain activity related to hunger and satiety, relevance of these findings to weight-loss maintenance has not been studied.

Objectives

We investigated effects of weight-loss maintenance diets varying in macronutrient content on regional cerebral blood flow (rCBF) in brain regions involved in hunger and reward.

Methods

In conjunction with a randomized controlled feeding trial, we investigated the effects of weight-loss maintenance diets varying in

SUBMITTER: Holsen LM 

PROVIDER: S-EPMC8349124 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature